Remedy Plan Therapeutics Associate Director, Preclinical Research Gaithersburg, MD · Full time Company website

Apply for Associate Director, Preclinical Research

Remedy Plan Therapeutics is a clinical-stage biotech company focused on developing NAMPT inhibitors for patients with acute leukemias and solid tumors. Our mission is to solve a decades-old medical-science puzzle: targeting NAD synthesis in cancer cells without damaging healthy cells. Our lead asset, RPT1G, is a novel, small-molecule NAMPT inhibitor designed for this purpose. Our team comprises experienced scientists, clinicians, and drug developers working together to bring hope to communities affected by these diseases. For more information on Remedy Plan, visit remedyplan.com and follow us on LinkedIn.

Key responsibilities

• Manage a small team of R&D scientists with a focus on career development and departmental excellence, including experimental execution and optimization
• Contribute directly to laboratory work and experiments (expect up to 40% hands-on lab work)
• Oversee daily lab operations, organization, and safety
• Design and execute mechanistic and efficacy studies in relevant disease models with CROs
• Help develop preclinical-to-clinical rationale including dose/schedule justification and biomarker strategy
• Contribute to IND-enabling study design and execution, including managing non-GLP and GLP toxicology programs at CROs
• Collaborate cross-functionally with Translational, Clinical Operations, CMC, Regulatory, and Business Development teams
• Interface with and support academic collaborators and advisors
• Present data internally and externally; contribute to publications, conference abstracts, and grant applications, may involve up to 10% travel for conferences or other meetings
• This role reports directly to the CSO and will collaborate closely with the Director, Translation Sciences, COO, and Director, Clinical Operations

Qualifications

Required

• Ph.D. in biochemistry, cancer biology, or a closely related discipline
• 5+ years of industry experience in drug development or a related field
• Experience with direct management of R&D scientists
• Hands-on expertise in cancer cell biology and in vivo pharmacology, including PK/PD study design and interpretation
• Proficiency with bioinformatics analysis (RNAseq, genomics, metabolomics, proteomics) and comfort handling and visualizing complex multi-modal datasets
• Experience supporting or leading IND-enabling programs, including CRO management and regulatory data package preparation
• Demonstrated ability to operate independently, prioritize effectively, and drive programs forward in a resource-constrained environment
• Desire to work in a fast-paced and exciting startup environment

Preferred

• Expertise in cancer metabolism
• Experience with translational biomarker development
• Prior experience in a startup or early-stage biotech; comfort wearing multiple hats