Searching for an experienced, new team member to share their knowledge + love of research to further the mission of Hesperos, Inc.
You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
You are conscientious and pay almost obsessive attention to detail, as organized documentation is second nature.
You are curious, love learning, and are eager to take on hard problems.
You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
You are resourceful and like to work independently but are not shy to ask for advice.
What You’ll Do
Keep detailed and organized records of experimental protocols and results
Design, optimize and oversee day-to-day experiments
Present findings and data analysis in research meetings.
Compile and interpret data and prepare presentations for management review
Assign tasks to and mentor junior scientists (research associates and research assistants)
Manage multiple projects (2-4) simultaneously ensuring each project meets required deliverables in an appropriate deadline
Develop a statement of work (SOW) and standard operating procedures (SOPs) for client contracts
Present data in client meetings
Establish and oversee quality control in all aspects of your team projects
Write and submit final reports and manuscripts under the guidance of a Senior Scientist at the conclusion of a project
Create, maintain, and curate human patient-derived cell sample biorepository, associated QC materials/reagents, and protocols for use/application
Contribute to the establishment of protocols for directed differentiation of human pluripotent cells to model a variety of cell types and diseases.
Support the development of disease phenotype-specific molecular and functional assays in relevant cell types differentiated from human pluripotent stem cells (such as enzymatic activity, receptor function, and metabolic assays).
Minimum Requirements: Master's with 3+ years or Ph.D. with 0+ years of experience.
Proficiency in common office software (typically Microsoft Word, Excel, and PowerPoint)
Ability to lead and mentor research associates
Experience with mammalian cell culture
Creativity and the ability to work with an interdisciplinary team to achieve technical and corporate milestones
Exceptional communication, critical thinking, and problem-solving skills
Knowledge of human pluripotent stem cell culture, characterization, and QC.
Experience with ESC/iPSC differentiation protocols, reprogramming techniques, and functional readouts.
Working knowledge of in vivo application of iPSC-derived cell models
Direct hands-on experience with a variety of cell-based and molecular biology readout technologies, such as flow cytometry immunophenotyping and analysis, FACS (cell sorting), qPCR, ELISA, and high-content and confocal imaging.
Ability to work on weekends when necessary.
Prior experience in:
Managing junior technicians and/or graduate or undergraduate researchers
Experience with Monday.com, Instagantt, and Python
Independent planning and execution of complex in vitro experiments
Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
Working knowledge of genome editing tools (CRISPR-Cas9, base editing, prime editing) is a plus