Hesperos, Inc. BBB Biologist - Scientist I/II Orlando, FL · Full time

Apply for BBB Biologist - Scientist I/II

About You 

• You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
• You are conscientious and pay almost obsessive attention to detail, as organized documentation is second nature. 
• You are curious, love learning, and are eager to take on hard problems. 
• You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
• You are resourceful and like to work independently but are not shy to ask for advice. 

What You’ll Do 

• Keep detailed and organized records of experimental protocols and results 
• Design, optimize and oversee day-to-day experiments 
• Present findings and data analysis in research meetings. 
• Compile and interpret data and prepare presentations for management review 
• Assign tasks to and mentor junior scientists (research associates and research assistants) 
• Manage multiple projects (2-4) simultaneously ensuring each project meets required deliverables by an appropriate deadline 
• Develop a statement of work (SOW) and standard operating procedures (SOPs) for client contracts
• Present data in client meetings 
• Establish and oversee quality control in all aspects of your team projects 
• Write and submit final reports and manuscripts under the guidance of a Senior Scientist at the conclusion of a project
• Develop models of barrier tissues (BBB, Kidney, GI tract)
• Measure efflux/influx transporter activity, tight junction formation, TEER, and transport kinetics 

Basic Qualifications 

• Minimum Requirements: Master's with 3+ years or Ph.D. with 0+ years of experience. 
• Proficiency in common office software (typically Microsoft Word, Excel, and PowerPoint)
• Ability to lead and mentor research associates 
• Experience with mammalian cell culture 
• Creativity and the ability to work with an interdisciplinary team to achieve technical and corporate milestones
• Exceptional communication, critical thinking, and problem-solving skills 
• Knowledge in culturing brain microvascular endothelial cells, astrocytes, pericytes, and models of the BBB
• Experience with TEER measurement methodologies
• Experience in transporter activity studies and modulation of transporter activity
• Ability to work on weekends when necessary.

Preferred Qualifications 

Prior experience in: 

• Managing junior technicians and/or graduate or undergraduate researchers 
• Experience with Monday.com, Instagantt, and Python 
• Independent planning and execution of complex in vitro experiments 
• Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
• Working knowledge of genome editing tools (CRISPR-Cas9, base editing, prime editing) is a plus
• Additional experience in glomerular and proximal tubule biology