Hesperos, Inc. BBB Biologist - Scientist I/II Orlando, FL · Full time

Searching for an experienced, new team member to share their knowledge + love of research to further the mission of Hesperos, Inc.


About You 

  • You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
  • You are conscientious and pay almost obsessive attention to detail, as organized documentation is second nature. 
  • You are curious, love learning, and are eager to take on hard problems. 
  • You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
  • You are resourceful and like to work independently but are not shy to ask for advice. 

What You’ll Do 

  • Keep detailed and organized records of experimental protocols and results 
  • Design, optimize and oversee day-to-day experiments 
  • Present findings and data analysis in research meetings. 
  • Compile and interpret data and prepare presentations for management review 
  • Assign tasks to and mentor junior scientists (research associates and research assistants) 
  • Manage multiple projects (2-4) simultaneously ensuring each project meets required deliverables by an appropriate deadline 
  • Develop a statement of work (SOW) and standard operating procedures (SOPs) for client contracts
  • Present data in client meetings 
  • Establish and oversee quality control in all aspects of your team projects 
  • Write and submit final reports and manuscripts under the guidance of a Senior Scientist at the conclusion of a project
  • Develop models of barrier tissues (BBB, Kidney, GI tract)
  • Measure efflux/influx transporter activity, tight junction formation, TEER, and transport kinetics 


Basic Qualifications 

  • Minimum Requirements: Master's with 3+ years or Ph.D. with 0+ years of experience. 
  • Proficiency in common office software (typically Microsoft Word, Excel, and PowerPoint)
  • Ability to lead and mentor research associates 
  • Experience with mammalian cell culture 
  • Creativity and the ability to work with an interdisciplinary team to achieve technical and corporate milestones
  • Exceptional communication, critical thinking, and problem-solving skills 
  • Knowledge in culturing brain microvascular endothelial cells, astrocytes, pericytes, and models of the BBB
  • Experience with TEER measurement methodologies
  • Experience in transporter activity studies and modulation of transporter activity
  • Ability to work on weekends when necessary.


Preferred Qualifications 

Prior experience in: 

  • Managing junior technicians and/or graduate or undergraduate researchers 
  • Experience with Monday.com, Instagantt, and Python 
  • Independent planning and execution of complex in vitro experiments 
  • Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
  • Working knowledge of genome editing tools (CRISPR-Cas9, base editing, prime editing) is a plus
  • Additional experience in glomerular and proximal tubule biology