EpiBiologics, Inc. Mass Spec Scientist Large Molecule Characterization (Temporary Contractor) San Mateo, CA · Contractor Company website

Apply for Mass Spec Scientist Large Molecule Characterization (Temporary Contractor)

We are a venture backed company with a mission to develop first-in-class and best-in-class antibody based targeted therapies against membrane and extracellular proteins that drive underlying disease biology. Protein degradation has the potential to eliminate disease causing proteins that were previously not addressable by classical therapeutic approaches. First generation protein degradation approaches can degrade intracellular proteins but do not address membrane and extracellular proteins, which are approximately 40% of the proteome. Our proprietary EpiTAC platform enables the development of first-in-class and best-in-class targeted therapies that degrade disease driving membrane and extracellular proteins. This approach can be effective against a wide range of disorders that lack meaningful treatment options today.

The candidate will apply state-of-the-art mass spectrometry to characterize protein therapeutics as well as analyze complex biological samples in proteomics studies.  

In this role you will be involved in multidisciplinary collaborations with other teams including protein science, biology, and translational sciences, to support the research and development of novel therapeutic bispecific antibodies.   

Responsibilities  

• Operate and maintain Orbitrap mass spectrometer and HPLC   
• Characterize antibody therapeutics using mass spec, including intact mass measurement, bispecific antibody chain pairing analysis, N-glycosylation analysis and PTM profiling through peptide mapping  
• Assist with proteomics experiments from study design, sample preparation to data analysis to understand the mechanism of action for novel therapeutic drugs  
• Maintain detailed experimental records  
• Communicate and collaborate across a diverse interdisciplinary team   

Required qualifications 

• BS degree required 
• Must be able to work onsite daily. 
• Experience with independent operation and maintenance of Orbitrap mass spectrometer and HPLC 
• In depth knowledge and extensive hands-on industrial experience with intact mass measurement, subunit analysis, peptide mapping, and N-glycosylation profiling 
• Strong understanding of antibody sequence liability and data interpretation in forced degradation samples 
• Experience with Xcalibur, Qual Browser, BioPharma finder and Byos is preferred 
• Experience with bispecific antibody and ADC is preferred  
• Experience with proteomics is a bonus but not required