Constantiam Biosciences Computational Scientist/Statistician Remote · Full time

In this role, you’ll take the lead on developing and evaluating generative models of massively multiplexed biophysical experiments for the purpose of inferring key quantities of interest.


About the job

Constantiam Biosciences is operating at the interface of the genomics and big data revolutions to push forward the fields of genetic variant interpretation and genetics-informed drug development to deliver better outcomes for patients. Founded and lead by scientists with deep research experience and a practical bent, Constantiam maintains a culture of openness and exploration while also staying focused on delivering for our customers. Constantiam has a proven track record of attracting non-dilutive funding and is just now starting on a project with a multi-year budget, giving this position good job security in an otherwise tumultuous market.

In this role, you’ll take the lead on developing and evaluating generative models of massively multiplexed biophysical experiments for the purpose of inferring key quantities of interest. This will entail understanding how these cutting-edge experiments are performed, identifying key possible sources of noise in the observed data, and determining how best to model these processes so as to make accurate and relevant inferences of biophysical parameters. Other projects will include using Natural Language Processing techniques to identify specific texts from among large corpi.

Constantiam Biosciences offers a dynamic and collaborative work environment, where you will be part of a tight-knit team of experienced professionals. As one of the first few full-time employees, you will have the opportunity to contribute to the direction and growth of the company, and interact with experienced subject matter experts from the industry and academia. We value self-motivation and a willingness to learn and teach others.

We believe diverse perspectives fuel innovation and drive success. We're committed to building an inclusive team that reflects the richness of our community.

If you are looking for an opportunity to expand your skill set and work with cutting-edge technologies in the field of genomics and genetics, we encourage you to apply for this position.

Specific Benefits:

  • Competitive salary: Commensurate with experience and qualifications
  • Equity: Own a piece of the company's success with our competitive equity program.
  • Health Plan: Stay healthy and secure with our comprehensive health insurance options.
  • 401(k): Invest in your future with our 401(k) plan.
  • PTOs: Unwind and recharge with generous paid time off, including sick leave and floating holidays.
  • Federal Holidays: Observe national holidays with paid time off.
  • Remote or Hybrid Work: Work where you thrive with our flexible remote or hybrid work arrangements.
  • Career growth, mentoring, and continuous learning. Everyone in the company is expected to continuous upskill and help others to do the same.


  • Read scientific literature to understand how experiments were performed and samples were collected
  • Create generative models of experimental and observational data using probabilistic programming frameworks like Pyro, PyMC, Stan, etc.
  • Evaluate generative models for predictive accuracy and calibrated uncertainty
  • Use Natural Language Processing tools to identify texts of interests from large text corpi
  • Work with the rest of the development team to build an integrated database and suite of applications that meet the needs of Constantiam’s customers

Minimum qualifications:

  • MS in a quantitative field
  • 5+ years experience with statistical data modeling and quantitative analyses

Preferred qualifications:

  • PhD in a quantitative field (science, math, engineering, etc.)
  • Experience with Bayesian statistical methods
  • Experience working with genomic data
  • Experience working with protein sequence and structure data
  • Experience with machine learning
  • Experience with Natural Language Processing
  • Strong programming skills
  • Experience working in cloud-based software systems

keywords: ML, NLP, Python, Pytorch/TensorFlow


$80,000 - $180,000 per year