Bioanalysis Redefined Sr. Scientist LC-MS, Scientific Development Team Newton, MA · Full time Company website

Apply for Sr. Scientist LC-MS, Scientific Development Team

Our Mission:

In a world where drug development is invariably a slow and inefficient process, we enable the biopharma industry to advance drugs faster and easier than has ever been possible with our deceptively simple, tech-driven platform

that delivers critical capabilities quickly and with consistently high quality.

Company Summary:

Now out of stealth, Dash Bio takes a technology-first approach to developing critical services across the drug development lifecycle. The company is building new capabilities that leverage AI, robotics, and fully-integrated software to fundamentally reinvent the way drugs are brought to market. Their first capability is a highly-automated clinical bioanalysis lab that promises to deliver GLP-compliant services with unprecedented speed.

Dash is led by an ambitious team of industry pros aligned on a shared vision and ethos. Founders include Dave Johnson (CEO), former Chief Data & AI Officer at Moderna; Ander Tallett (COO), CEO and founder of DigitalRadius and an experienced executive with stints at Moderna and Science Exchange; and Ely Porter, CTO and co-founder of Rootpath, a pioneer in synthetic immunology and gene synthesis.

Dash is targeting bioanalysis as an entry point for its intense potential for disruption to the current market with a

tech-first approach.

We are a place where employees are stretched to do the best work of their career. We are looking for engineers, scientists, and biotechnicians who want to make an impact on the world and leverage their skills in an innovative way.

Job Description:

We are seeking an experienced and innovative Senior Scientist with extensive LC/MS expertise to join our dynamic team. The ideal candidate will leverage their deep background in analytical development to lead the creation and implementation of advanced methods. This role offers the opportunity to integrate AI, robotics, and cutting-edge LC/MS assay techniques into our clinical bioanalysis platform. The successful candidate will drive projects from concept through completion, mentor junior staff, ensure adherence to regulatory standards, and deliver exceptional results in a fast-paced, innovation-driven environment.

Key Responsibilities:

Method Development:

• Design, develop, and optimize LC/MS-based bioanalytical assays, and implement them on automated platforms in collaboration with robotics engineers.
• Establish methods for identity, purity, aggregation status, charge isoforms, and potency using chromatography (including SEC, RP-HPLC, IEX, HIC, affinity, etc.) and other chemistry tools
• Select appropriate workflows for sample preparation, including protein precipitation, filtration, LLE, and SPE while facilitating their development on high-throughput automated platforms
• Drive experimental design and validation efforts for LC/MS-based bioanalysis to enhance sensitivity, specificity, throughput, and cost-effectiveness.
• Develop comprehensive verification and validation strategies ensuring robust and reproducible results.

Data Analysis and Interpretation:

• Utilize advanced statistical and analytical tools to process and interpret complex LC/MS datasets.
• Experience with deconvolution software (e.g., Compound Discoverer) and structural elucidation of non-targeted masses.
• Intact protein and fragment analysis for amino acid confirmation and qualification of post-translational modifications.
• Clearly communicate findings to internal teams and external clients, converting complex data into actionable insights that shape project strategies and regulatory submissions.

Technology Integration:

• Collaborate with cross-functional teams to seamlessly integrate AI-driven data analysis and robotics into LC/MS laboratory workflows.
• Evaluate and implement new analytical equipment, software, and instrumentation to further enhance lab capabilities and throughput.

Regulatory Compliance:

• Ensure all laboratory activities comply with GLP, QSR, and other relevant regulatory standards.
• Maintain meticulous design control documentation and support FDA regulatory audits.
• Oversee accessioning of critical reagents and sponsor samples, ensuring proper tracking, documentation, and maintenance of quality standards throughout the lab.

Project Leadership:

• Manage multiple LC/MS-centric projects simultaneously, maintaining strict timelines, quality compliance, and alignment with client and regulatory requirements.
• Mentor and train junior scientists and technicians, providing hands-on guidance in assay setup, method transfer, data interpretation, and adherence to SOPs.

• Client Collaboration:
• Partner closely with clients to define LC/MS assay requirements, experimental designs, timelines, and deliverables.
• Provide timely updates, data-driven reports, and presentations that meet or exceed client expectations.

Qualifications:

• Ph.D. in Biochemistry, Chemistry, Chemical Engineering, or a related field with 3+ years of industry experience; or M.S. with 6+ years of relevant experience.
• Demonstrated expertise in LC/MS method development, validation, and troubleshooting.
• Proven experience developing and validating regulated assays.
• Familiarity with regulatory requirements (GLP, ISO, FDA).
• Experience in design control documentation, technology transfer training, and SOP development.
• Exceptional project management skills with the ability to lead and perform in multidisciplinary teams in a regulated environment.
• Proficiency with data analysis software and statistical tools for assay optimization and validation.
• Excellent communication, interpersonal, and problem-solving abilities, with acute attention to detail.

• What We Offer:
• The chance to work at the cutting edge of bioanalytical innovation, where LC/MS plays a central role.
• A collaborative and inclusive culture that fosters professional growth, learning, and knowledge sharing.
• A competitive salary and comprehensive benefits package.
• Clear pathways for career advancement and ongoing professional development in an evolving industry.